CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family serine/threonine-protein kinase greatwall isoform X1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q96GX5
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q96GX5
GWL_HUMAN
Homo sapiens
Serine/threonine-protein kinase greatwall

PDB Structure

PDB 5LOH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct.
Ocasio, C.A., Rajasekaran, M.B., Walker, S., Le Grand, D., Spencer, J., Pearl, F.M., Ward, S.E., Savic, V., Pearl, L.H., Hochegger, H., Oliver, A.W.
Oncotarget
CATH-Gene3D is a Global Biodata Core Resource Learn more...