CATH Domain 5lnsA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	Pyridoxine biosynthesis protein PDX1

Enzyme Information

4.3.3.6

Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing).

based on mapping to UniProt Q8L940

D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate.

-!- The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel. -!- The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. -!- The enzyme complex is found in aerobic bacteria, archeae, fungi and plants.

UniProtKB Entries (1)

Q8L940

PDX13_ARATH

Arabidopsis thaliana

Pyridoxal 5'-phosphate synthase subunit PDX1.3

PDB Structure

PDB	5LNS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Rodrigues, M.J., Windeisen, V., Zhang, Y., Guedez, G., Weber, S., Strohmeier, M., Hanes, J.W., Royant, A., Evans, G., Sinning, I., Ealick, S.E., Begley, T.P., Tews, I. Nat. Chem. Biol.