CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | Pyridoxine biosynthesis protein PDX1 |
Enzyme Information
| 4.3.3.6 |
Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing).
based on mapping to UniProt Q8L940
D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate.
-!- The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel. -!- The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. -!- The enzyme complex is found in aerobic bacteria, archeae, fungi and plants.
|
UniProtKB Entries (1)
| Q8L940 |
PDX13_ARATH
Arabidopsis thaliana
Pyridoxal 5'-phosphate synthase subunit PDX1.3
|
PDB Structure
| PDB | 5LNR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis.
Nat. Chem. Biol.
|