CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Dual specificity protein kinase TTK

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt P33981
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P33981
TTK_HUMAN
Homo sapiens
Dual specificity protein kinase TTK

PDB Structure

PDB 5LJJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase.
Hiruma, Y., Koch, A., Dharadhar, S., Joosten, R.P., Perrakis, A.
Proteins