CATH Domain 5lixX00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.100	NADP-dependent oxidoreductase domain

Domain Context

CATH Clusters

Superfamily	NADP-dependent oxidoreductase domain
Functional Family	Aldo-keto reductase family 1 member B10

Enzyme Information

1.1.1.54

Allyl-alcohol dehydrogenase.

based on mapping to UniProt O60218

Allyl alcohol + NADP(+) = acrolein + NADPH.

-!- Also acts on saturated primary alcohols.

1.1.1.300

NADP-retinol dehydrogenase.

based on mapping to UniProt O60218

All-trans-retinol + NADP(+) = all-trans-retinal + NADPH.

-!- Greater catalytic efficiency in the reductive direction. -!- This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63. -!- Km-values for NADP(+) and NADPH are at least 800-fold lower than those for NAD(+) and NADH. -!- This enzyme differs from EC 1.1.1.105 which prefers NAD(+) and NADH. -!- Formerly EC 1.1.1.n2.

UniProtKB Entries (1)

O60218

AK1BA_HUMAN

Homo sapiens

Aldo-keto reductase family 1 member B10

PDB Structure

PDB	5LIX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. Cousido-Siah, A., Ruiz, F.X., Fanfrlik, J., Gimenez-Dejoz, J., Mitschler, A., Kamlar, M., Vesely, J., Ajani, H., Pares, X., Farres, J., Hobza, P., Podjarny, A.D. Acs Chem.Biol.