CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family |
Enzyme Information
| 1.3.1.82 |
(-)-isopiperitenone reductase.
based on mapping to UniProt Q6WAU1
(+)-cis-isopulegone + NADP(+) = (-)-isopiperitenone + NADPH.
-!- The reaction occurs in the opposite direction to that shown above. -!- Participates in the menthol-biosynthesis pathway of Mentha plants. -!- (+)-pulegone, (+)-cis-isopulegone and (-)-menthone are not substrates. -!- Has a preference for NADPH as the reductant, with NADH being a poor substitute. -!- Highly regioselective for the reduction of the endocyclic 1,2-double bond, and is stereoselective, producing only the 1R-configured product.
|
UniProtKB Entries (1)
| Q6WAU1 |
IPIPR_MENPI
Mentha x piperita
(-)-isopiperitenone reductase
|
PDB Structure
| PDB | 5L4S |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases.
Angew.Chem.Int.Ed.Engl.
|
