CATH Domain 5l3dA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.287	Helix Hairpins
	1.10.287.80	ATP synthase, gamma subunit, helix hairpin domain

Domain Context

CATH Clusters

Superfamily	ATP synthase, gamma subunit, helix hairpin domain
Functional Family	Lysine-specific histone demethylase 1A

Enzyme Information

1.-.-.-

Oxidoreductases.

based on mapping to UniProt O60341

UniProtKB Entries (1)

KDM1A_HUMAN

Homo sapiens

Lysine-specific histone demethylase 1A

PDB Structure

PDB	5L3D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors. Pilotto, S., Speranzini, V., Marabelli, C., Rusconi, F., Toffolo, E., Grillo, B., Battaglioli, E., Mattevi, A. Hum.Mol.Genet.