CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Lysine-specific histone demethylase 1A

Enzyme Information

1.-.-.-
Oxidoreductases.
based on mapping to UniProt O60341

UniProtKB Entries (1)

Q9UKL0
RCOR1_HUMAN
Homo sapiens
REST corepressor 1

PDB Structure

PDB 5L3C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors.
Pilotto, S., Speranzini, V., Marabelli, C., Rusconi, F., Toffolo, E., Grillo, B., Battaglioli, E., Mattevi, A.
Hum.Mol.Genet.
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