CATH Domain 5ktwA00

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.920	Histone Acetyltransferase; Chain A
	1.20.920.10	Bromodomain-like

Superfamily	Bromodomain-like
Functional Family	Histone acetyltransferase p300

2.3.1.48

Histone acetyltransferase.

based on mapping to UniProt Q92793

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.

-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.

CBP_HUMAN

Homo sapiens

CREB-binding protein

PDB	5KTW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. Crawford, T.D., Romero, F.A., Lai, K.W., Tsui, V., Taylor, A.M., de Leon Boenig, G., Noland, C.L., Murray, J., Ly, J., Choo, E.F., Hunsaker, T.L., Chan, E.W., Merchant, M., Kharbanda, S., Gascoigne, K.E., Kaufman, S., Beresini, M.H., Liao, J., Liu, W., Chen, K.X., Chen, Z., Conery, A.R., Cote, A., Jayaram, H., Jiang, Y., Kiefer, J.R., Kleinheinz, T., Li, Y., Maher, J., Pardo, E., Poy, F., Spillane, K.L., Wang, F., Wang, J., Wei, X., Xu, Z., Xu, Z., Yen, I., Zawadzke, L., Zhu, X., Bellon, S., Cummings, R., Cochran, A.G., Albrecht, B.K., Magnuson, S. J. Med. Chem.