CATH Domain 5kt2A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.270	Reverse transcriptase/Diguanylate cyclase domain

Domain Context

CATH Clusters

Superfamily	3.30.70.270
Functional Family	Polymerase (DNA directed) iota

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt Q9UNA4

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9UNA4

POLI_HUMAN

Homo sapiens

DNA polymerase iota

PDB Structure

PDB	5KT2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota. Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P. J.Biol.Chem.