CATH Domain 5krsA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family

Enzyme Information

UniProtKB Entries (1)

Q76353_9HIV1

Human immunodeficiency virus 1

Integrase

PDB Structure

PDB	5KRS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. Patel, D., Antwi, J., Koneru, P.C., Serrao, E., Forli, S., Kessl, J.J., Feng, L., Deng, N., Levy, R.M., Fuchs, J.R., Olson, A.J., Engelman, A.N., Bauman, J.D., Kvaratskhelia, M., Arnold, E. J.Biol.Chem.