CATH Domain 5knbB03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.100	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain Context

CATH Clusters

Superfamily	2.40.50.100
Functional Family	V-type proton ATPase catalytic subunit A

Enzyme Information

7.2.2.1

Na(+)-transporting two-sector ATPase.

based on mapping to UniProt Q08636

ATP + H(2)O + n Na(+)(Side 1) = ADP + phosphate + n Na(+)(Side 2).

-!- A multisubunit ATPase transporter found in some halophilic or alkalophilic bacteria that functions in maintaining sodium homeostasis. -!- The enzyme is similar to EC 7.1.2.2 but pumps Na(+) rather than H(+). -!- Cf. EC 7.2.2.3 and EC 7.2.2.4. -!- Formerly EC 3.6.3.15.

UniProtKB Entries (1)

Q08636

NTPA_ENTHA

Enterococcus hirae ATCC 9790

V-type sodium ATPase catalytic subunit A

PDB Structure

PDB	5KNB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structures of the ATP-binding and ADP-release dwells of the V1 rotary motor Suzuki, K., Mizutani, K., Maruyama, S., Shimono, K., Imai, F.L., Muneyuki, E., Kakinuma, Y., Ishizuka-Katsura, Y., Shirouzu, M., Yokoyama, S., Yamato, I., Murata, T. Nat Commun

Network disruptions