CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt Q47066
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

Q47066
BLT1_ECOLX
Escherichia coli
Beta-lactamase Toho-1

PDB Structure

PDB 5KMW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
TOHO1 Beta lactamase mutant E166A/R274N/R276N -benzyl penicillin complex
Coates, L., Langan, P.S., Vandavasi, V.G., Weiss, K.L., Cooper, J.B., Ginell, S.L.
to be published