CATH Domain 5kmoA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P04629

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P04629

NTRK1_HUMAN

Homo sapiens

High affinity nerve growth factor receptor

PDB Structure

PDB	5KMO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural characterization of nonactive site, TrkA-selective kinase inhibitors. Su, H.P., Rickert, K., Burlein, C., Narayan, K., Bukhtiyarova, M., Hurzy, D.M., Stump, C.A., Zhang, X., Reid, J., Krasowska-Zoladek, A., Tummala, S., Shipman, J.M., Kornienko, M., Lemaire, P.A., Krosky, D., Heller, A., Achab, A., Chamberlin, C., Saradjian, P., Sauvagnat, B., Yang, X., Ziebell, M.R., Nickbarg, E., Sanders, J.M., Bilodeau, M.T., Carroll, S.S., Lumb, K.J., Soisson, S.M., Henze, D.A., Cooke, A.J. Proc. Natl. Acad. Sci. U.S.A.