CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.270 | Reverse transcriptase/Diguanylate cyclase domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.270 |
| Functional Family | DNA polymerase eta |
Enzyme Information
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt Q9Y253
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
UniProtKB Entries (1)
| Q9Y253 |
POLH_HUMAN
Homo sapiens
DNA polymerase eta
|
PDB Structure
| PDB | 5KFE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science
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