CATH Classification

Domain Context

CATH Clusters

Superfamily 2.30.30.140
Functional Family Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q15047
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q15047
SETB1_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase SETDB1

PDB Structure

PDB 5KE3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a
Iqbal, A., Mader, P., Dong, A., Dobrovetsky, E., Ferreira de Freitas, R., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Schapira, M., Brown, P.J.
to be published
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