CATH Domain 5kbrA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q13153

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13153

PAK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase PAK 1

PDB Structure

PDB	5KBR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors. McCoull, W., Hennessy, E.J., Blades, K., Chuaqui, C., Dowling, J.E., Ferguson, A.D., Goldberg, F.W., Howe, N., Jones, C.R., Kemmitt, P.D., Lamont, G., Varnes, J.G., Ward, R.A., Yang, B. ACS Med Chem Lett