CATH Domain 5k0mA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.10	YVTN repeat-like/Quinoprotein amine dehydrogenase

Domain Context

CATH Clusters

Superfamily	YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family	Polycomb protein eed

Enzyme Information

UniProtKB Entries (1)

EED_HUMAN

Homo sapiens

Polycomb protein EED

PDB Structure

PDB	5K0M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. He, Y., Selvaraju, S., Curtin, M.L., Jakob, C.G., Zhu, H., Comess, K.M., Shaw, B., The, J., Lima-Fernandes, E., Szewczyk, M.M., Cheng, D., Klinge, K.L., Li, H.Q., Pliushchev, M., Algire, M.A., Maag, D., Guo, J., Dietrich, J., Panchal, S.C., Petros, A.M., Sweis, R.F., Torrent, M., Bigelow, L.J., Senisterra, G., Li, F., Kennedy, S., Wu, Q., Osterling, D.J., Lindley, D.J., Gao, W., Galasinski, S., Barsyte-Lovejoy, D., Vedadi, M., Buchanan, F.G., Arrowsmith, C.H., Chiang, G.G., Sun, C., Pappano, W.N. Nat. Chem. Biol.