CATH Domain 5k0iA00

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.120	Four Helix Bundle (Hemerythrin (Met), subunit A)
	1.20.120.550	Membrane associated eicosanoid/glutathione metabolism-like domain

Superfamily	Membrane associated eicosanoid/glutathione metabolism-like domain
Functional Family	Microsomal glutathione S-transferase 1

5.3.99.3

Prostaglandin-E synthase.

based on mapping to UniProt O14684

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.

-!- Brings about the opening of the epidioxy bridge.

PTGES_HUMAN

Homo sapiens

Prostaglandin E synthase

PDB	5K0I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors. Kuklish, S.L., Antonysamy, S., Bhattachar, S.N., Chandrasekhar, S., Fisher, M.J., Fretland, A.J., Gooding, K., Harvey, A., Hughes, N.E., Luz, J.G., Manninen, P.R., McGee, J.E., Navarro, A., Norman, B.H., Partridge, K.M., Quimby, S.J., Schiffler, M.A., Sloan, A.V., Warshawsky, A.M., York, J.S., Yu, X.P. Bioorg.Med.Chem.Lett.