CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.420 | Nucleotidyltransferase; domain 5 |
|
3.30.420.10 | Ribonuclease H-like superfamily/Ribonuclease H |
Domain Context
CATH Clusters
| Superfamily | Ribonuclease H-like superfamily/Ribonuclease H |
| Functional Family | Protein argonaute-2 |
Enzyme Information
| 3.1.26.n2 |
Argonaute-2.
based on mapping to UniProt Q9UKV8
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- The enzyme, isolated from animals, is required for RNA-mediated gene silencing (RNAi).
|
UniProtKB Entries (1)
| Q9UKV8 |
AGO2_HUMAN
Homo sapiens
Protein argonaute-2
|
PDB Structure
| PDB | 5JS1 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide.
J.Am.Chem.Soc.
|
