CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.150 | DNA polymerase; domain 1 |
|
1.10.150.50 | Transcription Factor, Ets-1 |
Domain Context
CATH Clusters
| Superfamily | Transcription Factor, Ets-1 |
| Functional Family | Poly [ADP-ribose] polymerase |
Enzyme Information
| 2.4.2.- |
Pentosyltransferases.
based on mapping to UniProt Q9H2K2
|
| 2.4.2.30 |
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt Q9H2K2
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
|
UniProtKB Entries (1)
| Q9H2K2 |
TNKS2_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase tankyrase-2
|
PDB Structure
| PDB | 5JRT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-beta-Catenin Signaling.
Mol.Cell
|