CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1580 | Nucleoside phosphorylase domain |
Domain Context
CATH Clusters
| Superfamily | Nucleoside phosphorylase domain |
| Functional Family | Aminodeoxyfutalosine nucleosidase |
Enzyme Information
| 3.2.2.9 |
Adenosylhomocysteine nucleosidase.
based on mapping to UniProt Q9ZMY2
S-adenosyl-L-homocysteine + H(2)O = S-(5-deoxy-D-ribos-5-yl)-L- homocysteine + adenine.
|
| 3.2.2.30 |
Aminodeoxyfutalosine nucleosidase.
based on mapping to UniProt Q9ZMY2
6-amino-6-deoxyfutalosine + H(2)O = dehypoxanthine futalosine + adenine.
-!- The enzyme, found in several bacterial species, catalyzes a step in a modified futalosine pathway for menaquinone biosynthesis. -!- While the enzyme from some organisms also has the activity of EC 3.2.2.9 the enzyme from Chlamydia trachomatis is specific for 6-amino-6-deoxyfutalosine.
|
UniProtKB Entries (1)
| Q9ZMY2 |
MQMTN_HELPJ
Helicobacter pylori J99
Aminodeoxyfutalosine nucleosidase
|
PDB Structure
| PDB | 5JPC |
| External Links | |
| Method | NEUTRON DIFFRACTION |
| Organism | |
| Primary Citation |
Neutron structures of the Helicobacter pylori 5'-methylthioadenosine nucleosidase highlight proton sharing and protonation states.
Proc. Natl. Acad. Sci. U.S.A.
|
