CATH Domain 5jctA01

Superfamily	Jelly Rolls
Functional Family	Pirin

1.13.11.24

Quercetin 2,3-dioxygenase.

based on mapping to UniProt O00625

Quercetin + O(2) = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H(+).

-!- Quercetin is a flavonol (5,7,3',4'-tetrahydroxyflavonol).

PIR_HUMAN

Homo sapiens

Pirin

PDB	5JCT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. Cheeseman, M.D., Chessum, N.E., Rye, C.S., Pasqua, A.E., Tucker, M.J., Wilding, B., Evans, L.E., Lepri, S., Richards, M., Sharp, S.Y., Ali, S., Rowlands, M., O'Fee, L., Miah, A., Hayes, A., Henley, A.T., Powers, M., Te Poele, R., De Billy, E., Pellegrino, L., Raynaud, F., Burke, R., van Montfort, R.L., Eccles, S.A., Workman, P., Jones, K. J. Med. Chem.