CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
Enzyme Information
| 1.1.1.267 |
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt Q8IKG4
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.
|
UniProtKB Entries (1)
| Q8IKG4 |
DXR_PLAF7
Plasmodium falciparum 3D7
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic
|
PDB Structure
| PDB | 5JAZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
Chemmedchem
|
