CATH Domain 5j9fA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.170	Formyl transferase, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Formyl transferase, N-terminal domain
Functional Family	Trifunctional purine biosynthetic protein adenosine-3

Enzyme Information

2.1.2.2	Phosphoribosylglycinamide formyltransferase. based on mapping to UniProt P22102 10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.
6.3.4.13	Phosphoribosylamine--glycine ligase. based on mapping to UniProt P22102 ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)- (5-phospho-D-ribosyl)glycinamide. -!- Formerly EC 6.3.1.3.
6.3.3.1	Phosphoribosylformylglycinamidine cyclo-ligase. based on mapping to UniProt P22102 ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

UniProtKB Entries (1)

PUR2_HUMAN

Homo sapiens

Trifunctional purine biosynthetic protein adenosine-3

PDB Structure

PDB	5J9F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. Golani, L.K., Wallace-Povirk, A., Deis, S.M., Wong, J., Ke, J., Gu, X., Raghavan, S., Wilson, M.R., Li, X., Polin, L., de Waal, P.W., White, K., Kushner, J., O'Connor, C., Hou, Z., Xu, H.E., Melcher, K., Dann, C.E., Matherly, L.H., Gangjee, A. J.Med.Chem.