CATH Domain 5j42A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.10	Deoxyribonuclease I; Chain A
	3.60.10.10	Endonuclease/exonuclease/phosphatase

Domain Context

CATH Clusters

Superfamily	Endonuclease/exonuclease/phosphatase
Functional Family	Tyrosyl-DNA phosphodiesterase 2

Enzyme Information

3.1.4.-

Phosphoric diester hydrolases.

based on mapping to UniProt Q9JJX7

UniProtKB Entries (1)

TYDP2_MOUSE

Mus musculus

Tyrosyl-DNA phosphodiesterase 2

PDB Structure

PDB	5J42
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Hornyak, P., Askwith, T., Walker, S., Komulainen, E., Paradowski, M., Pennicott, L.E., Bartlett, E.J., Brissett, N.C., Raoof, A., Watson, M., Jordan, A.M., Ogilvie, D.J., Ward, S.E., Atack, J.R., Pearl, L.H., Caldecott, K.W., Oliver, A.W. Biochem.J.