CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1490 | Dna Ligase; domain 1 |
|
3.30.1490.20 | ATP-grasp fold, A domain |
Domain Context
CATH Clusters
| Superfamily | ATP-grasp fold, A domain |
| Functional Family |
Enzyme Information
| 6.3.2.25 |
Tubulin--tyrosine ligase.
based on mapping to UniProt P38584
ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
-!- L-tyrosine is linked via a peptide bond to the C-terminus of de-tyrosinated alpha-tubulin (des-Tyr(omega)-alpha-tubulin). -!- The enzyme is highly specific for alpha-tubulin and moderately specific for ATP and L-tyrosine. -!- L-phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but with higher Km values.
|
UniProtKB Entries (2)
| P63043 |
STMN4_RAT
Rattus norvegicus
Stathmin-4
|
| P81947 |
TBA1B_BOVIN
Bos taurus
Tubulin alpha-1B chain
|
PDB Structure
| PDB | 5J2U |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.
Plos One
|
