CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt P49759
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P49759
CLK1_HUMAN
Homo sapiens
Dual specificity protein kinase CLK1

PDB Structure

PDB 5J1V
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure.
Esvan, Y.J., Zeinyeh, W., Boibessot, T., Nauton, L., Thery, V., Knapp, S., Chaikuad, A., Loaec, N., Meijer, L., Anizon, F., Giraud, F., Moreau, P.
Eur.J.Med.Chem.