CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family | Genome polyprotein |
Enzyme Information
| 3.4.22.28 |
Picornain 3C.
based on mapping to UniProt O91734
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
-!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
|
| 3.6.1.15 |
Nucleoside-triphosphate phosphatase.
based on mapping to UniProt O91734
NTP + H(2)O = NDP + phosphate.
-!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
|
| 2.7.7.48 |
RNA-directed RNA polymerase.
based on mapping to UniProt O91734
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
|
| 3.4.22.29 |
Picornain 2A.
based on mapping to UniProt O91734
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein.
-!- From entero- and rhinoviruses. -!- Smaller than the homologous virus picornain 3C. -!- Belongs to peptidase family C3.
|
UniProtKB Entries (1)
| O91734 |
POLG_EC01F
Echovirus 1 (strain Farouk / ATCC VR-1038)
Genome polyprotein
|
PDB Structure
| PDB | 5IYT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments.
Nat Commun
|