CATH Domain 5isyA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.79	Nucleoside Triphosphate Pyrophosphohydrolase
	3.90.79.10	Nucleoside Triphosphate Pyrophosphohydrolase

Domain Context

CATH Clusters

Superfamily	Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family	NADH pyrophosphatase

Enzyme Information

3.6.1.22

NAD(+) diphosphatase.

based on mapping to UniProt P32664

NAD(H) + H(2)O = AMP + NMN(H).

-!- This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences. -!- Also acts on other dinucleotides, including NADP(H), FAD(H(2)), and the thionicotinamide analogs of NAD(+) and NADP(+).

UniProtKB Entries (1)

P32664

NUDC_ECOLI

Escherichia coli K-12

NADH pyrophosphatase

PDB Structure

PDB	5ISY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis of prokaryotic NAD-RNA decapping by NudC Zhang, D., Liu, Y., Wang, Q., Guan, Z., Wang, J., Liu, J., Zou, T., Yin, P. Cell Res.