CATH Domain 5inoA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.10	Deoxyribonuclease I; Chain A
	3.60.10.10	Endonuclease/exonuclease/phosphatase

Domain Context

CATH Clusters

Superfamily	Endonuclease/exonuclease/phosphatase
Functional Family	Tyrosyl-DNA phosphodiesterase 2

Enzyme Information

3.1.4.-

Phosphoric diester hydrolases.

based on mapping to UniProt O95551

UniProtKB Entries (1)

TYDP2_HUMAN

Homo sapiens

Tyrosyl-DNA phosphodiesterase 2

PDB Structure

PDB	5INO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Schellenberg, M.J., Perera, L., Strom, C.N., Waters, C.A., Monian, B., Appel, C.D., Vilas, C.K., Williams, J.G., Ramsden, D.A., Williams, R.S. Nucleic Acids Res.