CATH Domain 5icsC00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	17-beta-hydroxysteroid dehydrogenase 14

Enzyme Information

1.1.1.-

With NAD(+) or NADP(+) as acceptor.

based on mapping to UniProt Q9BPX1

UniProtKB Entries (1)

DHB14_HUMAN

Homo sapiens

17-beta-hydroxysteroid dehydrogenase 14

PDB Structure

PDB	5ICS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	New Insights into Human 17 beta-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor. Bertoletti, N., Braun, F., Lepage, M., Moller, G., Adamski, J., Heine, A., Klebe, G., Marchais-Oberwinkler, S. J.Med.Chem.