CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family

Enzyme Information

2.1.1.128
(RS)-norcoclaurine 6-O-methyltransferase.
based on mapping to UniProt Q5C9L7
S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine.
-!- The enzyme will also catalyze the 6-O-methylation of (RS)- norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants.

UniProtKB Entries (1)

Q5C9L7
6OMT_THLFG
Thalictrum flavum subsp. glaucum
(RS)-norcoclaurine 6-O-methyltransferase

PDB Structure

PDB 5ICE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of norcoclaurine-6-O-methyltransferase, a key rate-limiting step in the synthesis of benzylisoquinoline alkaloids.
Robin, A.Y., Giustini, C., Graindorge, M., Matringe, M., Dumas, R.
Plant J.