CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.40 | Immunoglobulin-like |
|
2.60.40.700 | Diphtheria toxin, receptor-binding domain |
Domain Context
CATH Clusters
| Superfamily | Diphtheria toxin, receptor-binding domain |
| Functional Family | Diphtheria toxin |
Enzyme Information
| 2.4.2.36 |
NAD(+)--diphthamide ADP-ribosyltransferase.
based on mapping to UniProt Q6NK15
NAD(+) + diphthamide-[translation elongation factor 2] = nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2].
-!- Dihtheria toxin and some other bacterial toxins catalyze this reaction, which inactivates translation elongation factor 2 (EF2). -!- The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. -!- Cf. EC 2.4.2.31. -!- The relevant histidine of EF2 is His(715) in mammals, His(699) in yeast and His(600) in Pyrococcus horikoshii.
|
UniProtKB Entries (1)
| Q6NK15 |
Q6NK15_CORDI
Corynebacterium diphtheriae NCTC 13129
Diphtheria toxin
|
PDB Structure
| PDB | 5I82 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
First Crystal Structure of E.coli Based Recombinant Diphtheria Toxin Mutant CRM197.
To Be Published
|