CATH Domain 5hxbA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.30	Elongation Factor Tu (Ef-tu); domain 3
	2.40.30.10	Translation factors

Domain Context

CATH Clusters

Superfamily	Translation factors
Functional Family	Eukaryotic peptide chain release factor GTP-binding subunit

Enzyme Information

UniProtKB Entries (1)

DDB1_HUMAN

Homo sapiens

DNA damage-binding protein 1

PDB Structure

PDB	5HXB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Matyskiela, M.E., Lu, G., Ito, T., Pagarigan, B., Lu, C.C., Miller, K., Fang, W., Wang, N.Y., Nguyen, D., Houston, J., Carmel, G., Tran, T., Riley, M., Nosaka, L., Lander, G.C., Gaidarova, S., Xu, S., Ruchelman, A.L., Handa, H., Carmichael, J., Daniel, T.O., Cathers, B.E., Lopez-Girona, A., Chamberlain, P.P. Nature