CATH Classification

Domain Context

CATH Clusters

Superfamily Zn peptidases
Functional Family Carboxypeptidase B2

Enzyme Information

3.4.17.20
Carboxypeptidase U.
based on mapping to UniProt Q96IY4
Release of C-terminal Arg and Lys from a polypeptide.
-!- Pro-carboxypeptidase U in plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U. -!- Activity similar to that of the more stable lysine carboxypeptidase, except no preference is shown for Lys over Arg. -!- Belongs to peptidase family M14.

UniProtKB Entries (1)

Q96IY4
CBPB2_HUMAN
Homo sapiens
Carboxypeptidase B2

PDB Structure

PDB 5HVF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
Zhou, X., Weeks, S.D., Ameloot, P., Callewaert, N., Strelkov, S.V., Declerck, P.J.
J.Thromb.Haemost.