CATH Domain 5hs3A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family	Possible thymidylate synthase

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt P04818

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_HUMAN

Homo sapiens

Thymidylate synthase

PDB Structure

PDB	5HS3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil Almqvist, H., Axelsson, H., Jafari, R., Chen, D., Mateus, A., Haraldsson, M., Larsson, A., Molina, D.M., Artursson, P., Lundback, T., Nordlund, P. Nat Commun