CATH Domain 5ho7A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	3-phosphoinositide-dependent protein kinase 1

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O15530

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O15530

PDPK1_HUMAN

Homo sapiens

3-phosphoinositide-dependent protein kinase 1

PDB Structure

PDB	5HO7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of novel 7-azaindoles as PDK1 inhibitors. Wucherer-Plietker, M., Merkul, E., Muller, T.J., Esdar, C., Knochel, T., Heinrich, T., Buchstaller, H.P., Greiner, H., Dorsch, D., Finsinger, D., Calderini, M., Bruge, D., Gradler, U. Bioorg.Med.Chem.Lett.