CATH Domain 5h8bA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Casein kinase II subunit alpha

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P68400

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P68400

CSK21_HUMAN

Homo sapiens

Casein kinase II subunit alpha

PDB Structure

PDB	5H8B
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo. Dowling, J.E., Alimzhanov, M., Bao, L., Chuaqui, C., Denz, C.R., Jenkins, E., Larsen, N.A., Lyne, P.D., Pontz, T., Ye, Q., Holdgate, G.A., Snow, L., O'Connell, N., Ferguson, A.D. Acs Med.Chem.Lett.