CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family Glutathione peroxidase

Enzyme Information

1.11.1.12
Phospholipid-hydroperoxide glutathione peroxidase.
based on mapping to UniProt P36969
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H(2)O.
-!- The products of action of EC 1.13.11.12 on phospholipids can act as acceptor; H(2)O(2) can also act, but much more slowly (cf. EC 1.11.1.9).

UniProtKB Entries (1)

P36969
GPX4_HUMAN
Homo sapiens
Phospholipid hydroperoxide glutathione peroxidase

PDB Structure

PDB 5H5Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis
Sakamoto, K., Sogabe, S., Kamada, Y., Matsumoto, S.I., Kadotani, A., Sakamoto, J.I., Tani, A.
Biochem. Biophys. Res. Commun.