CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.30 | Glutaredoxin | |
3.40.30.10 | Glutaredoxin |
Domain Context
CATH Clusters
Superfamily | Glutaredoxin |
Functional Family | Glutathione peroxidase |
Enzyme Information
1.11.1.12 |
Phospholipid-hydroperoxide glutathione peroxidase.
based on mapping to UniProt P36969
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H(2)O.
-!- The products of action of EC 1.13.11.12 on phospholipids can act as acceptor; H(2)O(2) can also act, but much more slowly (cf. EC 1.11.1.9).
|
UniProtKB Entries (1)
P36969 |
GPX4_HUMAN
Homo sapiens
Phospholipid hydroperoxide glutathione peroxidase
|
PDB Structure
PDB | 5H5Q |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis
Biochem. Biophys. Res. Commun.
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