CATH Domain 5gwzA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1840	main proteinase (3clpro) structure, domain 3
	1.10.1840.10	main proteinase (3clpro) structure, domain 3

Domain Context

CATH Clusters

Superfamily	main proteinase (3clpro) structure, domain 3
Functional Family	Replicase polyprotein 1a

Enzyme Information

3.4.22.-

Cysteine endopeptidases.

based on mapping to UniProt P0C6V6

3.4.19.12

Ubiquitinyl hydrolase 1.

based on mapping to UniProt P0C6V6

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

P0C6V6

R1A_PEDV7

Porcine epidemic diarrhea virus CV777

Replicase polyprotein 1a

PDB Structure

PDB	5GWZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus Wang, F., Chen, C., Yang, K., Xu, Y., Liu, X., Gao, F., Liu, H., Chen, X., Zhao, Q., Liu, X., Cai, Y., Yang, H. J. Med. Chem.