CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Probable ATP-dependent RNA helicase DDX41

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt Q9UJV9
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q9UJV9
DDX41_HUMAN
Homo sapiens
Probable ATP-dependent RNA helicase DDX41

PDB Structure

PDB 5GVR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide
Omura, H., Oikawa, D., Nakane, T., Kato, M., Ishii, R., Ishitani, R., Tokunaga, F., Nureki, O.
Sci Rep
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