CATH Domain 5gueC00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family

Enzyme Information

4.2.3.146

Cyclooctat-9-en-7-ol synthase.

based on mapping to UniProt C9K1X5

Geranylgeranyl diphosphate + H(2)O = cyclooctat-9-en-7-ol + diphosphate.

-!- Isolated from the bacterium Streptomyces melanosporofaciens, where it is part of the biosynthesis of cyclooctatin, a potent inhibitor of lysophospholipase.

UniProtKB Entries (1)

C9K1X5

COTB2_STRMJ

Streptomyces melanosporofaciens

Cyclooctat-9-en-7-ol synthase

PDB Structure

PDB	5GUE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol Tomita, T., Kim, S.-Y., Teramoto, K., Meguro, A., Ozaki, T., Yoshida, A., Motoyoshi, Y., Mori, N., Ishigami, K., Watanabe, H., Nishiyama, M., Kuzuyama, T. ACS Chem. Biol.