CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family

Enzyme Information

4.2.3.146
Cyclooctat-9-en-7-ol synthase.
based on mapping to UniProt C9K1X5
Geranylgeranyl diphosphate + H(2)O = cyclooctat-9-en-7-ol + diphosphate.
-!- Isolated from the bacterium Streptomyces melanosporofaciens, where it is part of the biosynthesis of cyclooctatin, a potent inhibitor of lysophospholipase.

UniProtKB Entries (1)

C9K1X5
COTB2_STRMJ
Streptomyces melanosporofaciens
Cyclooctat-9-en-7-ol synthase

PDB Structure

PDB 5GUE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol
Tomita, T., Kim, S.-Y., Teramoto, K., Meguro, A., Ozaki, T., Yoshida, A., Motoyoshi, Y., Mori, N., Ishigami, K., Watanabe, H., Nishiyama, M., Kuzuyama, T.
ACS Chem. Biol.