CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt Q00536
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q00536
CDK16_HUMAN
Homo sapiens
Cyclin-dependent kinase 16

PDB Structure

PDB 5G6V
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the Pctaire1 Kinase in Complex with Inhibitor
Dixon-Clarke, S.E., Shehata, S., Sakamoto, K., Bullock, A.
To be Published