CATH Domain 5fx6A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Genome polyprotein

Enzyme Information

3.4.22.29	Picornain 2A. based on mapping to UniProt P04936 Selective cleavage of Tyr-\|-Gly bond in the picornavirus polyprotein. -!- From entero- and rhinoviruses. -!- Smaller than the homologous virus picornain 3C. -!- Belongs to peptidase family C3.
2.7.7.48	RNA-directed RNA polymerase. based on mapping to UniProt P04936 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.4.22.28	Picornain 3C. based on mapping to UniProt P04936 Selective cleavage of Gln-\|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. -!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
3.6.1.15	Nucleoside-triphosphate phosphatase. based on mapping to UniProt P04936 NTP + H(2)O = NDP + phosphate. -!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.

UniProtKB Entries (1)

POLG_HRV2

Human rhinovirus A2

Genome polyprotein

PDB Structure

PDB	5FX6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design and Structure-Activity Relationships of Novel Inhibitors of Human Rhinovirus 3C Protease. Kawatkar, S.P., Gagnon, M., Hoesch, V., Tiong-Yip, C., Johnson, K., Ek, M., Nilsson, E., Lister, T., Olsson, L., Patel, J., Yu, Q. Bioorg.Med.Chem.Lett.