CATH Classification
Level | CATH Code | Description |
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2 | Mainly Beta |
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2.60 | Sandwich |
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2.60.40 | Immunoglobulin-like |
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2.60.40.1730 | tricorn interacting facor f3 domain |
Domain Context
CATH Clusters
Superfamily | tricorn interacting facor f3 domain |
Functional Family | Leukotriene A(4) hydrolase |
Enzyme Information
3.3.2.6 |
Leukotriene-A(4) hydrolase.
based on mapping to UniProt P09960
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
-!- A bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities. -!- It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates. -!- It also converts leukotriene A(4) into leukotriene B(4), unlike EC 3.2.2.10 which converts leukotriene A(4) into 5,6-dihydroxy- 7,9,11,14-eicosatetraenoic acid.
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UniProtKB Entries (1)
P09960 |
LKHA4_HUMAN
Homo sapiens
Leukotriene A-4 hydrolase
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PDB Structure
PDB | 5FWQ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Thermodynamic properties of leukotriene A4hydrolase inhibitors.
Bioorg.Med.Chem.
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