CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.510 | Transferase(Phosphotransferase); domain 1 | |
1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
Superfamily | Transferase(Phosphotransferase) domain 1 |
Functional Family | Cyclin-dependent kinase 6 |
Enzyme Information
2.7.11.22 |
Cyclin-dependent kinase.
based on mapping to UniProt P11802
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.
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UniProtKB Entries (1)
P08238 |
HS90B_HUMAN
Homo sapiens
Heat shock protein HSP 90-beta
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PDB Structure
PDB | 5FWK |
External Links | |
Method | ELECTRON MICROSCOPY |
Organism | |
Primary Citation |
Atomic Structure of Hsp90-Cdc37-Cdk4 Reveals that Hsp90 Traps and Stabilizes an Unfolded Kinase.
Science
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