CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Cyclin-dependent kinase 6

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P11802
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P08238
HS90B_HUMAN
Homo sapiens
Heat shock protein HSP 90-beta

PDB Structure

PDB 5FWK
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Atomic Structure of Hsp90-Cdc37-Cdk4 Reveals that Hsp90 Traps and Stabilizes an Unfolded Kinase.
Verba, K.A., Wang, R.Y., Arakawa, A., Liu, Y., Shirouzu, M., Yokoyama, S., Agard, D.A.
Science