CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.40 | Immunoglobulin-like |
|
2.60.40.180 | Transthyretin/hydroxyisourate hydrolase domain |
Domain Context
CATH Clusters
| Superfamily | Transthyretin/hydroxyisourate hydrolase domain |
| Functional Family | Transthyretin |
Enzyme Information
UniProtKB Entries (1)
| P02766 |
TTHY_HUMAN
Homo sapiens
Transthyretin
|
PDB Structure
| PDB | 5FW6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
Sci Rep
|
