CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotidyltransferases domain 2
Functional Family focal adhesion kinase 1 isoform X1

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P34152
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P34152
FAK1_MOUSE
Mus musculus
Focal adhesion kinase 1

PDB Structure

PDB 5F28
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
FAK Forms a Complex with MEF2 to Couple Biomechanical Signaling to Transcription in Cardiomyocytes.
Cardoso, A.C., Pereira, A.H.M., Ambrosio, A.L.B., Consonni, S.R., Rocha de Oliveira, R., Bajgelman, M.C., Dias, S.M.G., Franchini, K.G.
Structure
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